Oral Paracetamol for Closure of Patent Ductus Arteriosus in Selected Preterm Neonates.

We prospectively studied the effect of oral paracetamol in closing hemodynamically significant Patent ductus arteriosus in preterm infants (gestational age <32 weeks) where Ibuprofen was contraindicated. 29 of 40 neonates (72.5%) showed successful response while 11 (29.5%) failed to show any response. No major complications were seen.

Alveolar Capillary Dysplasia as a Cause of Persistent Pulmonary Hypertension.

Background: Persistent pulmonary hypertension (PPHN) in a term or late preterm has varied etiology. Case characteristics: A late preterm neonate operated for esophageal atresia with tracheo-esophageal fistula was complicated by severe pulmonary hypertension and unable to be weaned off from respiratory support. Outcome: The neonate expired by 15 weeks of life; diagnosis was made on postmortem lung biopsy. Message: Alveolarcapillary dysplasia should be considered in a neonate with idiopathic refractory PPHN, if associated with anomalies